Atherosclerosis is a chronic, inflammatory process (inflammation) which leads to degeneration of the arterial vessel wall through the storage of cholesterol and fatty acids. Atherosclerosis is the starting point for a number of stenotic vascular diseases such as coronary heart disease. Deciphering the pathomechanisms is a basic prerequisite for preventing the progression of atherosclerosis and maintaining health into old age.

Among the most common structural heart diseases are pathologies of the heart valves. Heart valves can become inadequate or stenotic over time and place a considerable burden on the cardiovascular system. Research into modern treatment methods is essential given the increasing prevalence of heart disease in old age.

Glucose is one of the most important sources of energy. The correct breakdown, supply and storage of glucose is a basic requirement for the functionality of the human body. Disorders of glucose metabolism play a prominent role in cardiovascular, endocrinological and inflammatory diseases. This is why this subject area is a research focus of the CRI CM.

Chronic inflammation is present in numerous diseases (e.g. cardiovascular diseases, diabetes mellitus). Cellular metabolism plays a decisive role in the regulation of these inflammatory processes and immunity. Our research focuses on the investigation of metabolic changes in cells and how these regulate inflammatory reactions in the context of cardiovascular diseases.

In particular, research into the physiological and pathophysiological mechanisms of epicardial adipose tissue is the focus of the CRI CM.

Diseases of the aorta (aortopathies) include aortic dissection or aortic aneurysm. These are potentially life-threatening diseases that must be recognized and treated in good time.

Omics refers to a group of scientific fields that study large-scale biological data, such as genes (genomics), proteins (proteomics) and metabolites (metabolomics). These approaches help our understanding of how genetic and environmental factors interact to influence health and disease. In cardiovascular and metabolic diseases, omics technologies can identify genetic risk factors, detect early disease markers, and uncover molecular pathways involved in conditions like heart disease, diabetes, and obesity. Omics data can help with the development of personalized treatments and preventive strategies to improve patient outcomes.

Environmental factors like fine dust, toxins, and microplastics can contribute to cardiovascular and metabolic diseases by causing chronic inflammation, oxidative stress, and disruptions in metabolism. Exposure to environmental toxins has been linked to heart disease, high blood pressure, diabetes, and obesity. Understanding these risks can help promote policies and lifestyle changes that reduce exposure and protect long-term health.