The skin is the largest organ of the human body. It is a barrier protecting humans from dehydration, heat, cold, and also diverse pathogens. Unfortunately, many people are also affected by diseases of the skin, from inflammatory diseases to white skin cancer and melanoma. The immune system plays a major role in the development of most skin diseases. We at the Department of Dermatology and Venereology at the JKU Linz are primarily concerned with the interaction of skin cells with immune cells. Our focus is on rare tumor diseases of the skin and (rare) inflammatory skin diseases. We try not only to investigate the underlying mechanisms, but also to provide patients with rare diseases, for which there are often no approved drugs, with personalized treatment through targeted molecular biological analyses. For our projects and experiments we use bioinformatics in all facets, from machine learning to the application and evaluation of high-throughput methods.