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Forschungsseminar am Institut für Angewandte Statistik

13. Juni:

Prof. em. Emmanuel Lesaffre, I-Biostat, KU Leuven, Belgium: The use of historical data in clinical trials: Does it pay off?

Emmanuel Lesaffre

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Meeting-ID: 280 519 2121
Passwort: 584190

Abstract:

This non-technical review discusses the use of historical data in the design and analysis of randomized controlled trials using a Bayesian approach. The focus is on comparing the philosophy behind different approaches and practical considerations for their use. The two main approaches, i.e. the power prior and the meta-analytic-predictive prior, are illustrated using fictitious and real data sets. Such methods, which are known as dynamic borrowing methods, are becoming increasingly popular in pharmaceutical research because they may imply an important reduction in costs. In some cases, e.g. in pediatric studies, they may be indispensable to address the clinical research question. In addition to the two original approaches, this review also covers various extensions and variations of the methods. The usefulness and acceptance of the approaches by regulatory agencies is also critically evaluated.

 

Event

Datum & Uhrzeit

13.06.2024

15:30 - 17:00 Uhr

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Ort

S2 Z74, Science Park 2

Kontakt

alexandra.stadler@jku.at